BDBM665696 US20240116918, Example 1

SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)CN3CCc4ccccc4C3)CC3(CC3)c2cn1

InChI Key InChIKey=GIIXXTIREUPXSF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 665696   

TargetProtein arginine N-methyltransferase 5(Human)
NANJING SANHOME PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM665696(US20240116918, Example 1)
Affinity DataIC50: 32.7nMAssay Description:Experimental Method2.1. Preparation of reaction buffer and reaction stop solution: the composition of 1× reaction buffer was 10 mM Tris-HCl, pH 8.0; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 5(Human)
NANJING SANHOME PHARMACEUTICAL CO., LTD.

US Patent
LigandPNGBDBM665696(US20240116918, Example 1)
Affinity DataIC50: 33nMAssay Description:Inhibition of PRMT5 (unknown origin) using H4(1-21)S1ac as substrate preincubated for 15 mins followed by substrate addition and measured for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed