BDBM665708 US20240116922, Example 10

SMILES CC(C)Oc1nc2nc(cn2cc1C(=O)Nc1cccn(C2CC2)c1=O)C12CC(CF)(C1)OC2

InChI Key InChIKey=UZMGYPMSBWYDHD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 665708   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Biogen Inc.

Curated by ChEMBL
LigandPNGBDBM665708(US20240116922, Example 10)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human IRAK4 using biotinylated peptide substrate incubated for 3 hrs by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Biogen Inc.

Curated by ChEMBL
LigandPNGBDBM665708(US20240116922, Example 10)
Affinity DataIC50: 0.800nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent