BDBM667280 2-oxo-N-(3-(2,2,2- trifluoroethyl)-9H-xanthen- 9-yl)-6-(trifluoromethyl)- 1,2-dihydropyridine-3- carboxamide::US11957687, Compound 141

SMILES FC(F)(F)Cc1ccc2C(NC(=O)c3ccc([nH]c3=O)C(F)(F)F)c3ccccc3Oc2c1

InChI Key InChIKey=DOBDETZVFYFXQU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 667280   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667280(US11957687, Compound 141 | 2-oxo-N-(3-(2,2,2- trif...)
Affinity DataIC50: 360nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667280(US11957687, Compound 141 | 2-oxo-N-(3-(2,2,2- trif...)
Affinity DataIC50: 3.62E+3nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B1 function, an enzymatic blocking assay was performed. For the assay, HSD17B1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667280(US11957687, Compound 141 | 2-oxo-N-(3-(2,2,2- trif...)
Affinity DataIC50: 7.30E+3nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B2 function, an enzymatic blocking assay was performed. For the assay, HSD17B2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target3-hydroxyacyl-CoA dehydrogenase type-2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667280(US11957687, Compound 141 | 2-oxo-N-(3-(2,2,2- trif...)
Affinity DataIC50: 3.00E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B10 function, an enzymatic blocking assay was performed. For the assay, HSD17B1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667280(US11957687, Compound 141 | 2-oxo-N-(3-(2,2,2- trif...)
Affinity DataIC50: 5.83E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B4 function, an enzymatic blocking assay was performed. For the assay, HSD17B4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent