BDBM667283 N-(phenyl(4-(pyridin-3- yl)phenyl)methyl)-2-oxo-6- (trifluoromethyl)-1,2- dihydropyridine-3- carboxamide::US11957687, Compound 93

SMILES FC(F)(F)c1ccc(C(=O)NC(c2ccccc2)c2ccc(cc2)-c2cccnc2)c(=O)[nH]1

InChI Key InChIKey=OWFYSQZTVWTQKY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 667283   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667283(US11957687, Compound 93 | N-(phenyl(4-(pyridin-3- ...)
Affinity DataIC50: 600nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667283(US11957687, Compound 93 | N-(phenyl(4-(pyridin-3- ...)
Affinity DataIC50: 1.07E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B2 function, an enzymatic blocking assay was performed. For the assay, HSD17B2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667283(US11957687, Compound 93 | N-(phenyl(4-(pyridin-3- ...)
Affinity DataIC50: 1.56E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B1 function, an enzymatic blocking assay was performed. For the assay, HSD17B1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target3-hydroxyacyl-CoA dehydrogenase type-2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667283(US11957687, Compound 93 | N-(phenyl(4-(pyridin-3- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B10 function, an enzymatic blocking assay was performed. For the assay, HSD17B1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667283(US11957687, Compound 93 | N-(phenyl(4-(pyridin-3- ...)
Affinity DataIC50: 6.62E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B4 function, an enzymatic blocking assay was performed. For the assay, HSD17B4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent