BDBM668007 (R)-N-(1-(1-(2,4- bis(trifluoromethyl)phenyl)ethyl)- 1H-pyrazol-4-yl)-3-(pyridin-2- yl)isoxazole-5-carboxamide::US20240124434, Compound 76

SMILES C[C@H](c1ccc(cc1C(F)(F)F)C(F)(F)F)n1cc(NC(=O)c2cc(no2)-c2ccccn2)cn1

InChI Key InChIKey=PSWNDTMQCQCITD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 668007   

TargetCytochrome P450 2C8(Human)
Altos Labs

US Patent
LigandPNGBDBM668007(US20240124434, Compound 76 | (R)-N-(1-(1-(2,4- bis...)
Affinity DataIC50: 1.14E+3nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2C19(Human)
Altos Labs

US Patent
LigandPNGBDBM668007(US20240124434, Compound 76 | (R)-N-(1-(1-(2,4- bis...)
Affinity DataIC50: 3.60E+3nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Altos Labs

US Patent
LigandPNGBDBM668007(US20240124434, Compound 76 | (R)-N-(1-(1-(2,4- bis...)
Affinity DataIC50: 6.00E+3nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2B6(Human)
Altos Labs

US Patent
LigandPNGBDBM668007(US20240124434, Compound 76 | (R)-N-(1-(1-(2,4- bis...)
Affinity DataIC50: 6.45E+3nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Altos Labs

US Patent
LigandPNGBDBM668007(US20240124434, Compound 76 | (R)-N-(1-(1-(2,4- bis...)
Affinity DataIC50: 7.54E+3nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Altos Labs

US Patent
LigandPNGBDBM668007(US20240124434, Compound 76 | (R)-N-(1-(1-(2,4- bis...)
Affinity DataIC50: 5.00E+4nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Altos Labs

US Patent
LigandPNGBDBM668007(US20240124434, Compound 76 | (R)-N-(1-(1-(2,4- bis...)
Affinity DataIC50: 5.00E+4nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent