BDBM668179 US20240124450, Example 26A

SMILES CSc1cc(cc(OC[C@@]2(N)CCC(F)(F)C2)c1C#N)-c1cnc2ccccn12

InChI Key InChIKey=AWVUPXUQWGNTHF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 668179   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 668179BDBM668179(US20240124450, Example 26A)
Affinity DataIC50: 0.600nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 668179BDBM668179(US20240124450, Example 26A)
Affinity DataIC50: 1nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 668179BDBM668179(US20240124450, Example 26A)
Affinity DataIC50: 3nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent