BDBM668252 1-methyl-7-(trifluoromethyl)-5-(2-(trifluoromethyl)pyridin-3-yl)-1,5-dihydro-4H-imidazo[4,5-c][1,8]naphthyridin-4-one ::US20240124454, Compound 41::US20240124454, Compound 41-P2

SMILES Cn1cnc2c1c1ccc(nc1n(-c1cccnc1C(F)(F)F)c2=O)C(F)(F)F

InChI Key InChIKey=MERJIPOVEPHVLW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 668252   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Nanjing Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM668252(US20240124454, Compound 41-P2 | 1-methyl-7-(triflu...)
Affinity DataIC50: 22.3nMAssay Description:The brief introduction of the test principle: L-methionine and ATP can be converted into SAM, inorganic phosphate, and inorganic diphosphate under th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Nanjing Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM668252(US20240124454, Compound 41-P2 | 1-methyl-7-(triflu...)
Affinity DataIC50: 56.8nMAssay Description:The brief introduction of the test principle: L-methionine and ATP can be converted into SAM, inorganic phosphate, and inorganic diphosphate under th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Nanjing Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM668252(US20240124454, Compound 41-P2 | 1-methyl-7-(triflu...)
Affinity DataIC50: 1.82E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Nanjing Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM668252(US20240124454, Compound 41-P2 | 1-methyl-7-(triflu...)
Affinity DataIC50: 3.00E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Nanjing Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM668252(US20240124454, Compound 41-P2 | 1-methyl-7-(triflu...)
Affinity DataIC50: 3.00E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent