BDBM668265 7-chloro-5-(2-cyclopropylpyridin-3-yl)-1-methyl-1,5-dihydro-4H-imidazo[4,5-c]quinolin-4-one ::US20240124454, Compound 49::US20240124454, Compound 49-P2

SMILES Cn1cnc2c1-c3ccc(cc3N(C2=O)c4cccnc4C5CC5)Cl

InChI Key InChIKey=FELOKFNJXFDCKP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 668265   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668265(7-chloro-5-(2-cyclopropylpyridin-3-yl)-1-methyl-1,...)
Affinity DataIC50: 18.7nMAssay Description:The brief introduction of the test principle: L-methionine and ATP can be converted into SAM, inorganic phosphate, and inorganic diphosphate under th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668265(7-chloro-5-(2-cyclopropylpyridin-3-yl)-1-methyl-1,...)
Affinity DataIC50: 28.1nMAssay Description:The brief introduction of the test principle: L-methionine and ATP can be converted into SAM, inorganic phosphate, and inorganic diphosphate under th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668265(7-chloro-5-(2-cyclopropylpyridin-3-yl)-1-methyl-1,...)
Affinity DataIC50: 3.00E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668265(7-chloro-5-(2-cyclopropylpyridin-3-yl)-1-methyl-1,...)
Affinity DataIC50: 3.00E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668265(7-chloro-5-(2-cyclopropylpyridin-3-yl)-1-methyl-1,...)
Affinity DataIC50: 3.00E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent