BDBM668298 5-(2-cyclopropylpyridin-3-yl)-7-(trifluoromethyl)oxazolo[4,5-c][1,8]naphthyridin-4(5H)-one ::US20240124454, Compound 81::US20240124454, Compound 81-P2

SMILES FC(F)(F)c1ccc2c3ocnc3c(=O)n(-c3cccnc3C3CC3)c2n1

InChI Key InChIKey=IFPJRPIMCOERRP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 668298   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668298(US20240124454, Compound 81 | 5-(2-cyclopropylpyrid...)
Affinity DataIC50: 36.2nMAssay Description:The brief introduction of the test principle: L-methionine and ATP can be converted into SAM, inorganic phosphate, and inorganic diphosphate under th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668298(US20240124454, Compound 81 | 5-(2-cyclopropylpyrid...)
Affinity DataIC50: 52.3nMAssay Description:The brief introduction of the test principle: L-methionine and ATP can be converted into SAM, inorganic phosphate, and inorganic diphosphate under th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668298(US20240124454, Compound 81 | 5-(2-cyclopropylpyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668298(US20240124454, Compound 81 | 5-(2-cyclopropylpyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Nanjing Zaiming Pharmaceutical

US Patent
LigandPNGBDBM668298(US20240124454, Compound 81 | 5-(2-cyclopropylpyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:I. Experimental materials and instruments1. Human liver microsome (Corning 452117)2. NADPH (Solarbio 705Y021)3. Positive substrates diclofenac (Sigma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent