BDBM668352 N-(azepan-4-yl)-3-[5-(trifluoromethyl)-2-thienyl] imidazo[1,2-b] pyrid azin-6-amine ::US20240124469, Compound 28

SMILES FC(F)(F)c1ccc(s1)-c1cnc2ccc(NC3CCCNCC3)nn12

InChI Key InChIKey=NQYXWPVKCRLVMD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 668352   

TargetSerine/threonine-protein kinase pim-1(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandPNGBDBM668352(US20240124469, Compound 28 | N-(azepan-4-yl)-3-[5-...)
Affinity DataIC50: 2nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandPNGBDBM668352(US20240124469, Compound 28 | N-(azepan-4-yl)-3-[5-...)
Affinity DataIC50: 55nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandPNGBDBM668352(US20240124469, Compound 28 | N-(azepan-4-yl)-3-[5-...)
Affinity DataIC50: 550nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent