BDBM668361 US20240124469, Compound 47::[(2R,5S)-5-[[3-[5-(trifluoromethyl)-2-thienyl]imidazo[1,2-b]pyridazin-6-yl]amino]tetrahydropyran-2-yl]methanol

SMILES OC[C@H]1CC[C@@H](CO1)Nc1ccc2ncc(-c3ccc(s3)C(F)(F)F)n2n1

InChI Key InChIKey=FOMQAXLFFZQXNC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 668361   

TargetSerine/threonine-protein kinase pim-1(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandPNGBDBM668361(US20240124469, Compound 47 | [(2R,5S)-5-[[3-[5-(tr...)
Affinity DataIC50: 55nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandPNGBDBM668361(US20240124469, Compound 47 | [(2R,5S)-5-[[3-[5-(tr...)
Affinity DataIC50: 5.50E+3nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandPNGBDBM668361(US20240124469, Compound 47 | [(2R,5S)-5-[[3-[5-(tr...)
Affinity DataIC50: 1.00E+4nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent