BDBM668628 2-(4-Cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]benzamide::US11964950, Compound A-1

SMILES [#6]-[#7]S(=O)(=O)[#7-]([Na+])-c1nccc(-[#6]-c2cc(-[#6](-[#7])=O)c(-[#7]-c3ccc(cc3F)-[#6]-3-[#6]-[#6]-3)c(F)c2F)c1F

InChI Key InChIKey=

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 668628   

TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM668628(2-(4-Cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[...)
Affinity DataIC50: 1nMAssay Description:The BRAF-inhibiting activity of the compounds listed in Table 3 below was evaluated by the time-resolved fluorescence-fluorescence resonance energy t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM668628(2-(4-Cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[...)
Affinity DataIC50: 17nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent