BDBM669888 Example 5 of WO2019023417A1::US20240132517, Example TPX-0022

SMILES CCN1Cc2c(ccc(c2C#N)F)O[C@H](CNC(=O)c3c(nn4c3nc1cc4)N)C

InChI Key InChIKey=UUDPUQDMSHQSKH-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 669888   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM669888(US20240132517, Example TPX-0022 | Example 5 of WO...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM669888(US20240132517, Example TPX-0022 | Example 5 of WO...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM669888(US20240132517, Example TPX-0022 | Example 5 of WO...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM669888(US20240132517, Example TPX-0022 | Example 5 of WO...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHepatocyte growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM669888(US20240132517, Example TPX-0022 | Example 5 of WO...)
Affinity DataIC50: 1.80nMAssay Description:The operation method is briefly described as follows:The powders of the compound were dissolved in 100% DMSO to make a 10 mM stock solution. The init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM669888(US20240132517, Example TPX-0022 | Example 5 of WO...)
Affinity DataIC50: 7.5nMAssay Description:The operation method is briefly described as follows:The powders of the compound were dissolved in 100% DMSO to make a 10 mM stock solution. The init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM669888(US20240132517, Example TPX-0022 | Example 5 of WO...)
Affinity DataIC50: 10nMAssay Description:The operation method is briefly described as follows:The powders of the compound were dissolved in 100% DMSO to make a 10 mM stock solution. The init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent