BDBM669915 Production of 3-(5-acetylthiophen-2-yl)-3-(3-{[(R)-4-ethyl-1,1-dioxide-3,4-dihydro-2H-pyrido[4,3-b][1,4,5]oxathiazepin-2-yl]methyl}-4-methylphenyl)-2,2-dimethylpropanoic acid ::US20240132519, Compound 48::US20240132519, Compound C1::US20240132519, Compound D1

SMILES CC[C@@H]1CN(Cc2cc(ccc2C)C(c2ccc(s2)C(C)=O)C(C)(C)C(O)=O)S(=O)(=O)c2cnccc2O1

InChI Key InChIKey=HSUSGYADAICRPE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 669915   

LigandPNGBDBM669915(US20240132519, Compound 48 | Production of 3-(5-ac...)
Affinity DataIC50: 0.150nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669915(US20240132519, Compound 48 | Production of 3-(5-ac...)
Affinity DataIC50: 0.170nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669915(US20240132519, Compound 48 | Production of 3-(5-ac...)
Affinity DataIC50: 0.390nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent