BDBM670783 (6R)-N-(3,3-difluoro-1- (hydroxymethyl)cyclopentyl)-3-(3- (difluoromethoxy)phenyl)-1-(5- fluoropyridin-2-yl)-4,5,6,7- tetrahydro-1H-indazole-6- carboxamide (3rd eluting with AD-H column, 35% EtOH/CO2)::US20240140938, Example 8a::US20240140938, Example 8b

SMILES OCC1(CCC(F)(F)C1)NC(=O)[C@@H]1CCc2c(C1)n(nc2-c1cccc(OC(F)F)c1)-c1ccc(F)cn1

InChI Key InChIKey=CHTRFQKLADJXIP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670783   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670783((6R)-N-(3,3-difluoro-1- (hydroxymethyl)cyclopentyl...)
Affinity DataIC50: 5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670783((6R)-N-(3,3-difluoro-1- (hydroxymethyl)cyclopentyl...)
Affinity DataIC50: 35nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent