BDBM670806 (R)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-isopropyl-N-(4- methyl-1,1-dioxidotetrahydro-2H- thiopyran-4-yl)-4,5,6,7-tetrahydro- 1H-indazole-6-carboxamide::US20240140938, Example 30::US20240140938, Example 46

SMILES CC(C)n1nc(c2CC[C@H](Cc12)C(=O)NC1(C)CCS(=O)(=O)CC1)-c1cc(OC(F)F)ccc1F

InChI Key InChIKey=GYPLIPMWCRIIBP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670806   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670806((R)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-isop...)
Affinity DataIC50: 5.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670806((R)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-isop...)
Affinity DataIC50: 37.9nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent