BDBM670829 (R)-N-(4-cyano-1,1- dioxidotetrahydro-2H-thiopyran-4- yl)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-(propan-2-yl-d7)- 4,5,6,7-tetrahydro-1H-indazole-6- carboxamide::US20240140938, Example 51::US20240140938, Example 52

SMILES CC(C)n1nc(c2CC[C@H](Cc12)C(=O)NC1(CCS(=O)(=O)CC1)C#N)-c1cc(OC(F)F)ccc1F

InChI Key InChIKey=OGRAOFHTJRXJJY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670829   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670829(US20240140938, Example 52 | (R)-N-(4-cyano-1,1- di...)
Affinity DataIC50: 4.30nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670829(US20240140938, Example 52 | (R)-N-(4-cyano-1,1- di...)
Affinity DataIC50: 4.70nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent