BDBM670831 (6R)-3-(2-ethoxy-5-fluoropyridin-4- yl)-N-(4-methyl-1,1- dioxidotetrahydro-2H-thiopyran-4- yl)-1-(1,1,1-trifluoropropan-2-yl)- 4,5,6,7-tetrahydro-1H-indazole-6- carboxamide (faster eluting with: OD-H column, 20% MeOH/CO2)::US20240140938, Example 53a::US20240140938, Example 53b

SMILES CCOc1cc(-c2nn(C(C)C(F)(F)F)c3C[C@@H](CCc23)C(=O)NC2(C)CCS(=O)(=O)CC2)c(F)cn1

InChI Key InChIKey=IYZJNVZODAIQPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670831   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670831(US20240140938, Example 53b | (6R)-3-(2-ethoxy-5-fl...)
Affinity DataIC50: 10.3nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670831(US20240140938, Example 53b | (6R)-3-(2-ethoxy-5-fl...)
Affinity DataIC50: 162nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent