BDBM670837 (6R)-1-(1-cyclopropylethyl)-3-(5- (difluoromethoxy)-2-fluorophenyl)- N-(3-methyl-1,1-dioxidothietan-3- yl)-4,5,6,7-tetrahydro-1H-indazole- 6-carboxamide (faster eluting with IC column, 35% MeOH/CO2)::US20240140938, Example 58a::US20240140938, Example 58b

SMILES CC(C1CC1)n1nc(c2CC[C@H](Cc12)C(=O)NC1(C)CS(=O)(=O)C1)-c1cc(OC(F)F)ccc1F

InChI Key InChIKey=XFNRTYZHUWQIHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670837   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670837(US20240140938, Example 58b | (6R)-1-(1-cyclopropyl...)
Affinity DataIC50: 2.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670837(US20240140938, Example 58b | (6R)-1-(1-cyclopropyl...)
Affinity DataIC50: 23.4nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent