BDBM670840 (6R)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-isopropyl-N-(1- (isopropylcarbamoyl)-3- methylpyrrolidin-3-yl)-4,5,6,7- tetrahydro-1H-indazole-6- carboxamide (mixture of diastereomers)::US20240140938, Example 60

SMILES CC(C)NC(=O)N1CCC(C)(C1)NC(=O)[C@@H]1CCc2c(C1)n(nc2-c1cc(OC(F)F)ccc1F)C(C)C

InChI Key InChIKey=UCSVIGLVRSZNAS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 670840   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670840(US20240140938, Example 60 | (6R)-3-(5-(difluoromet...)
Affinity DataIC50: 29.2nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent