BDBM670889 (6R)-3-(2-ethoxy-5-fluoropyridin- 4-yl)-1-(3-hydroxy-3- methylbutan-2-yl)-N-(4-methyl- 1,1-dioxidotetrahydro-2H- thiopyran-4-yl)-4,5,6,7- tetrahydro-1H-indazole-6- carboxamide (slower eluting with OJ-H column, 10% MeOH/CO2)::US20240140938, Example 109a::US20240140938, Example 109b

SMILES CCOc1cc(-c2nn(C(C)C(C)(C)O)c3C[C@@H](CCc23)C(=O)NC2(C)CCS(=O)(=O)CC2)c(F)cn1

InChI Key InChIKey=HQKSMWSJYUXLIW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670889   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670889(US20240140938, Example 109b | (6R)-3-(2-ethoxy-5-f...)
Affinity DataIC50: 30.7nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670889(US20240140938, Example 109b | (6R)-3-(2-ethoxy-5-f...)
Affinity DataIC50: 49.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent