BDBM670909 3-(5-(difluoromethoxy)-2- fluorophenyl)-1-isopropyl-N-(3- methyl-1,1-dioxidothietan-3-yl)- 1,5,6,7-tetrahydropyrano[3,2- c]pyrazole-6-carboxamide (mixture of enantiomers)::US20240140938, Example 121

SMILES CC(C)n1nc(c2OCC(Cc12)C(=O)NC1(C)CS(=O)(=O)C1)-c1cc(OC(F)F)ccc1F

InChI Key InChIKey=NRESPCYPZQSCCR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 670909   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670909(US20240140938, Example 121 | 3-(5-(difluoromethoxy...)
Affinity DataIC50: 21.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent