BDBM670910 3-(5-(difluoromethoxy)-2- fluorophenyl)-1-isopropyl-N-((S)-3- methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1,5,6,7-tetrahydropyrano[3,2- c]pyrazole-6-carboxamide (mixture of diastereomers)::US20240140938, Example 122

SMILES CC(C)n1nc(c2OCC(Cc12)C(=O)N[C@@]1(C)CCS(=O)(=O)C1)-c1cc(OC(F)F)ccc1F

InChI Key InChIKey=FRNKVFCNFWITQZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 670910   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670910(US20240140938, Example 122 | 3-(5-(difluoromethoxy...)
Affinity DataIC50: 5.80nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent