BDBM672498 (5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-butyl)-29-(3-chloro-4-(trifluoromethyl)phenethyl)-35-(cyclohexylmethyl)-18-cyclopentyl-11-isobutyl-N,N,5,6,12,16,19,33,36-nonamethyl-4,7,10,13,17,20,23,28,31,34,37-undecaoxotetratriacontahydro-2H,4H-spiro[azeto[2,1-u]pyrrolo[2,1-i][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotetratriacontine-21,1'-cyclopentane]-15-carboxamide::US20240148821, Compound 1777

SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)N(C)C(=O)C[C@H](N(C)C(=O)[C@H](C2CCCC2)N(C)C(=O)C2(CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCc2ccc(c(Cl)c2)C(F)(F)F)NC(=O)CN(C)C(=O)[C@H](CC2CCCCC2)N(C)C(=O)[C@@H]2CCN2C(=O)[C@H](C)N(C)C1=O)C(=O)N(C)C

InChI Key InChIKey=CKXOWGKJLADMGE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 672498   

TargetGTPase KRas(Human)
Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM672498((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-b...)
Affinity DataKd:  0.160nMAssay Description:Binding affinity to biotinylated KRAS G12D mutant (unknown origin) incubated for 120 mins by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672498((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-b...)
Affinity DataIC50: 0.630nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2024
Entry Details
US Patent