BDBM674216 3,5-difluoro-4- hydroxy-N- {[(1r,4r)-4-{6-[1- methyl-5-(trifluoro- methyl)-1H-pyrazol- 4-yl]-2H-indazol-2- yl}cyclohexyl] methyl}benzamide::US20240150334, Example 46

SMILES Cn1ncc(-c2ccc3cn([C@H]4CC[C@H](CNC(=O)c5cc(F)c(O)c(F)c5)CC4)nc3c2)c1C(F)(F)F

InChI Key InChIKey=PCTXOESCHVNTAX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674216   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 674216BDBM674216(3,5-difluoro-4- hydroxy-N- {[(1r,4r)-4-{6-[1- meth...)
Affinity DataIC50: 9.5nMAssay Description:HSD17B13 uses the oxidized form of nicotinamide adenine dinucleotide (NAD+) as a cofactor during metabolism of beta-estradiol (substrate), converting...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
Entry Details
US Patent