BDBM674224 N-({(1r,4r)-4-[6-(5- cyclopropylpyrimidin- 2-yl)-2H-indazol-2- yl]cyclohexyl} methyl)-3,5-difluoro- 4-hydroxybenzamide::US20240150334, Example 54

SMILES O=C(NC[C@H]1CC[C@H](n2cc3ccc(-c4ncc(C5CC5)cn4)cc3n2)CC1)c1cc(F)c(O)c(F)c1

InChI Key InChIKey=DDPAERXZDMIWAH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674224   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 674224BDBM674224(N-({(1r,4r)-4-[6-(5- cyclopropylpyrimidin- 2-yl)-2...)
Affinity DataIC50: 8.70nMAssay Description:HSD17B13 uses the oxidized form of nicotinamide adenine dinucleotide (NAD+) as a cofactor during metabolism of beta-estradiol (substrate), converting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent