BDBM674226 N-({(1r,4r)-4- [6-(2-cyanophenyl)- 2H-indazol-2-yl] cyclohexyl}methyl)- 3,5-difluoro-4- hydroxybenzamide::US20240150334, Example 56

SMILES N#Cc1ccccc1-c1ccc2cn([C@H]3CC[C@H](CNC(=O)c4cc(F)c(O)c(F)c4)CC3)nc2c1

InChI Key InChIKey=XLMAUODTKRUJRF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 674226   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 674226BDBM674226(N-({(1r,4r)-4- [6-(2-cyanophenyl)- 2H-indazol-2-yl...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human HSD17B13 using estradiol and NAD as substrate incubated for 2 hrs by Envision plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 674226BDBM674226(N-({(1r,4r)-4- [6-(2-cyanophenyl)- 2H-indazol-2-yl...)
Affinity DataIC50: 5.60nMAssay Description:HSD17B13 uses the oxidized form of nicotinamide adenine dinucleotide (NAD+) as a cofactor during metabolism of beta-estradiol (substrate), converting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent