BDBM674278 3,5-difluoro-4- hydroxy-N-({(1r,4r)- 4-[6-(2-methoxy- pyrimidin-4-yl)-2H- indazol-2-yl] cyclohexyl}methyl) benzamide::US20240150334, Example 109

SMILES COc1nccc(-c2ccc3cn([C@H]4CC[C@H](CNC(=O)c5cc(F)c(O)c(F)c5)CC4)nc3c2)n1

InChI Key InChIKey=YFFHSRJDCTUOBC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674278   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 674278BDBM674278(3,5-difluoro-4- hydroxy-N-({(1r,4r)- 4-[6-(2-metho...)
Affinity DataIC50: 5.5nMAssay Description:HSD17B13 uses the oxidized form of nicotinamide adenine dinucleotide (NAD+) as a cofactor during metabolism of beta-estradiol (substrate), converting...More data for this Ligand-Target Pair
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Date in BDB:
8/9/2024
Entry Details
US Patent