BDBM674283 3,5-difluoro-4- hydroxy-N-{[(1r,4r)- 4-{6-[2-(morpholin- 4-yl)-1,3-thiazol-4- yl]-2H-indazol-2- yl}cyclohexyl]methyl} benzamide::US20240150334, Example 114

SMILES O=C(NC[C@H]1CC[C@H](n2cc3ccc(-c4csc(N5CCOCC5)n4)cc3n2)CC1)c1cc(F)c(O)c(F)c1

InChI Key InChIKey=HPDMEZVFJUGFPI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674283   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 674283BDBM674283(3,5-difluoro-4- hydroxy-N-{[(1r,4r)- 4-{6-[2-(morp...)
Affinity DataIC50: 8.60nMAssay Description:HSD17B13 uses the oxidized form of nicotinamide adenine dinucleotide (NAD+) as a cofactor during metabolism of beta-estradiol (substrate), converting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent