BDBM674399 US20240150366, Example 3

SMILES Cc1c(F)cc2[nH]ncc2c1-c1c(cc2c(nc(OC3CCOCC3)nc2c1OCc1ccc(Cc2ncn(n2)C2COC2)cc1)N1C[C@@H]2C[C@H]1CN2)C1CC1

InChI Key InChIKey=AOLXSHDVFDPVTE-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674399   

TargetKRAS (G12D)/Son of Sevenless Homolog 1 (SOS)/RAF Proto-Oncogene Serine/Threonine-Protein Kinase (c-Raf)(Human)
Astellas Pharma

US Patent

LigandBDBM674399(US20240150366, Example 3)Copy SMILESCopy InChI

Affinity DataIC50: 75nMAssay Description:Using human recombinant KRAS G12D, SOS and c-Raf proteins, the inhibitory activity of subject compounds on the complex formation of the proteins was ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
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