BDBM674405 US20240150366, Example 9

SMILES Cc1cc(C)n2cc(Cc3ccc(COc4c(c(cc5c(nc(OC6CCOCC6)nc45)N4C[C@@H]5C[C@H]4CN5)C4CC4)-c4c(C)c(F)cc5[nH]ncc45)cc3)nc2n1

InChI Key InChIKey=HMGBJLJXQDHTQP-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674405   

TargetKRAS (G12D)/Son of Sevenless Homolog 1 (SOS)/RAF Proto-Oncogene Serine/Threonine-Protein Kinase (c-Raf)(Human)
Astellas Pharma

US Patent

LigandBDBM674405(US20240150366, Example 9)Copy SMILESCopy InChI

Affinity DataIC50: 44nMAssay Description:Using human recombinant KRAS G12D, SOS and c-Raf proteins, the inhibitory activity of subject compounds on the complex formation of the proteins was ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
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