BDBM674409 US20240150366, Example 10

SMILES CC(C)c1ncccc1COc1nc(N2C[C@@H]3C[C@H]2CN3)c2cc(C3CC3)c(c(OCc3ccc(Cn4c5cccnc5n(C)c4=O)cc3)c2n1)-c1c(C)c(F)cc2[nH]ncc12

InChI Key InChIKey=BYDURIJPZPINBK-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674409   

TargetKRAS (G12D)/Son of Sevenless Homolog 1 (SOS)/RAF Proto-Oncogene Serine/Threonine-Protein Kinase (c-Raf)(Human)
Astellas Pharma

US Patent

LigandBDBM674409(US20240150366, Example 10)Copy SMILESCopy InChI

Affinity DataIC50: 33nMAssay Description:Using human recombinant KRAS G12D, SOS and c-Raf proteins, the inhibitory activity of subject compounds on the complex formation of the proteins was ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL