BDBM674410 US20240150366, Example 11

SMILES Cc1nc(nn1Cc1ccc(COc2c(c(cc3c(nc(OC4CCOCC4)nc23)N2C[C@@H]3C[C@H]2CN3)C2CC2)-c2c(C)c(F)cc3[nH]ncc23)cc1)-c1cnccn1

InChI Key InChIKey=NGBAFFCCXQJEHL-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674410   

TargetKRAS (G12D)/Son of Sevenless Homolog 1 (SOS)/RAF Proto-Oncogene Serine/Threonine-Protein Kinase (c-Raf)(Human)
Astellas Pharma

US Patent

LigandBDBM674410(US20240150366, Example 11)Copy SMILESCopy InChI

Affinity DataIC50: 110nMAssay Description:Using human recombinant KRAS G12D, SOS and c-Raf proteins, the inhibitory activity of subject compounds on the complex formation of the proteins was ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL