BDBM674420 US20240150366, Example 23

SMILES CN1CC(=O)N(Cc2ccc(COc3c(c(cc4c(nc(OC5CCOCC5)nc34)N3C[C@@H]4C[C@H]3CN4)C3CC3)-c3c(C)c(F)cc4[nH]ncc34)cc2)c2cccnc12

InChI Key InChIKey=GIWIBBUBJKNZKY-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674420   

TargetKRAS (G12D)/Son of Sevenless Homolog 1 (SOS)/RAF Proto-Oncogene Serine/Threonine-Protein Kinase (c-Raf)(Human)
Astellas Pharma

US Patent

LigandBDBM674420(US20240150366, Example 23)Copy SMILESCopy InChI

Affinity DataIC50: 68nMAssay Description:Using human recombinant KRAS G12D, SOS and c-Raf proteins, the inhibitory activity of subject compounds on the complex formation of the proteins was ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
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