BDBM674685 US20240158368, Compound 32

SMILES CO[C@H]1CN(C[C@@H]1NC(=O)c1cc(=O)[nH]c2c(F)cccc12)c1c(cc(cc1C(F)(F)F)C#N)C(=O)N1CCOCC1

InChI Key InChIKey=HJFRBDXSQSKVKW-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 674685   

TargetReplicase polyprotein 1ab(2019-nCoV)
Abbvie

US Patent
LigandPNGBDBM674685(US20240158368, Compound 32)
Affinity DataEC50:  0.450nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
US Patent

TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM674685(US20240158368, Compound 32)
Affinity DataEC50:  1.06nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-OC43)
Abbvie

US Patent
LigandPNGBDBM674685(US20240158368, Compound 32)
Affinity DataEC50:  1.17nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-229E)
Abbvie

US Patent
LigandPNGBDBM674685(US20240158368, Compound 32)
Affinity DataEC50:  1.78nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
US Patent