BDBM675275 US20240158414, Example 31

SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)ccnc1Cl)-c1ccc(C)cn1)C(F)(F)F

InChI Key InChIKey=FNIQIUPHKJHOAK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 675275   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM675275(US20240158414, Example 31)
Affinity DataIC50: 0.274nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
US Patent