BDBM676689 US20240166645, Compound I-1

SMILES C[C@@H](Nc1nc(C)nc2cc(=O)n(cc12)C1(CF)CC1)c1cccc(c1C)S(=O)(=O)C(F)F

InChI Key InChIKey=HMYKKIYAYJFFPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 676689   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Wuhan Humanwell Innovative Drug

US Patent
LigandPNGBDBM676689(US20240166645, Compound I-1)
Affinity DataIC50: 6.87nMAssay Description:Table 1: The compound to be tested was prepared into a 10 mM stock solution with DMSO, and the compound was serially diluted using 1× test buffer. 0....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Wuhan Humanwell Innovative Drug

US Patent
LigandPNGBDBM676689(US20240166645, Compound I-1)
Affinity DataIC50: 59nMAssay Description:Table 2: The compound to be tested was prepared into a 10 mM stock solution with DMSO, and serially diluted using 1× test buffer (modified Tris buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent