BDBM677034 N-(3-((6-((1-methyl-1H- pyrazol-4-yl)-1H-pyrazolo[3,4- d]pyrimidine-1- yl)methyl)phenyl)acrylamide::US11993603, Example 2

SMILES Cn1cc(Nc2ncc3cnn(Cc4cccc(NC(=O)C=C)c4)c3n2)cn1

InChI Key InChIKey=OVIYRHXLFVAREZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677034   

TargetTyrosine-protein kinase JAK3(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677034(US11993603, Example 2 | N-(3-((6-((1-methyl-1H- py...)
Affinity DataIC50: 2.20nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677034(US11993603, Example 2 | N-(3-((6-((1-methyl-1H- py...)
Affinity DataIC50: 941nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677034(US11993603, Example 2 | N-(3-((6-((1-methyl-1H- py...)
Affinity DataIC50: 1.39E+3nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent