BDBM677036 N-(3-((6-aniline-1H- pyrazolo[3,4-d]pyrimidin-1- yl)methyl)phenyl)acrylamide::US11993603, Example 4

SMILES C=CC(=O)Nc1cccc(Cn2ncc3cnc(Nc4ccccc4)nc23)c1

InChI Key InChIKey=IRVXIKOOKQKCAS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677036   

TargetTyrosine-protein kinase JAK3(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677036(US11993603, Example 4 | N-(3-((6-aniline-1H- pyraz...)
Affinity DataIC50: 1.10nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677036(US11993603, Example 4 | N-(3-((6-aniline-1H- pyraz...)
Affinity DataIC50: 901nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677036(US11993603, Example 4 | N-(3-((6-aniline-1H- pyraz...)
Affinity DataIC50: 1.12E+3nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent