BDBM677041 N-(3-((6-((1-methyl-1H-pyrazol-4- yl)amino)-1H-pyrazolo[3,4- d]pyrimidin-1- yl)methyl)phenyl)but-2-enamide;::US11993603, Example 9

SMILES C\C=C\C(=O)Nc1cccc(Cn2ncc3cnc(Nc4cnn(C)c4)nc23)c1

InChI Key InChIKey=OSDVCXUZTASGJJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677041   

TargetTyrosine-protein kinase JAK3(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677041(US11993603, Example 9 | N-(3-((6-((1-methyl-1H-pyr...)
Affinity DataIC50: 2.10nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677041(US11993603, Example 9 | N-(3-((6-((1-methyl-1H-pyr...)
Affinity DataIC50: 618nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677041(US11993603, Example 9 | N-(3-((6-((1-methyl-1H-pyr...)
Affinity DataIC50: 860nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent