BDBM677043 N-(3-((6-aniline-1H-pyrazolo[3,4- d]pyrimidin-1- yl)methyl)phenyl)but-2-enamide::US11993603, Example 11

SMILES C\C=C\C(=O)Nc1cccc(Cn2ncc3cnc(Nc4ccccc4)nc23)c1

InChI Key InChIKey=FCLAHSRDWHWVOZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677043   

TargetTyrosine-protein kinase JAK3(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677043(US11993603, Example 11 | N-(3-((6-aniline-1H-pyraz...)
Affinity DataIC50: 1.40nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677043(US11993603, Example 11 | N-(3-((6-aniline-1H-pyraz...)
Affinity DataIC50: 690nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677043(US11993603, Example 11 | N-(3-((6-aniline-1H-pyraz...)
Affinity DataIC50: 830nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent