BDBM677045 N-(3-((6-((4- morpholinylphenyl)amino)-1H- pyrazolo[3,4-d]pyrimidin-1- yl)methyl)phenyl)but-2-enamide;::US11993603, Example 13

SMILES C\C=C\C(=O)Nc1cccc(Cn2ncc3cnc(Nc4ccc(cc4)N4CCOCC4)nc23)c1

InChI Key InChIKey=GQHBYXDQTGGNKR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677045   

TargetTyrosine-protein kinase JAK3(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677045(US11993603, Example 13 | N-(3-((6-((4- morpholinyl...)
Affinity DataIC50: 0.400nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677045(US11993603, Example 13 | N-(3-((6-((4- morpholinyl...)
Affinity DataIC50: 710nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677045(US11993603, Example 13 | N-(3-((6-((4- morpholinyl...)
Affinity DataIC50: 890nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent