BDBM677054 N-(4-((6-((1-(2-methoxy-ethyl)-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)methyl)phenyl)but-2-enamide::US11993603, Example 22

SMILES COCCn1cc(Nc2ncc3cnn(Cc4ccc(NC(=O)C=CC)cc4)c3n2)cn1

InChI Key InChIKey=AOBBXNBARGFFGO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677054   

TargetTyrosine-protein kinase JAK3(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677054(US11993603, Example 22 | N-(4-((6-((1-(2-methoxy-e...)
Affinity DataIC50: 2nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677054(US11993603, Example 22 | N-(4-((6-((1-(2-methoxy-e...)
Affinity DataIC50: 918nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677054(US11993603, Example 22 | N-(4-((6-((1-(2-methoxy-e...)
Affinity DataIC50: 1.25E+3nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent