BDBM677056 N-(4-((6-((1-(2-hydroxyethyl)- 1H-pyrazol-4-yl)amino)-1H- pyrazolo[3,4-d]pyrimidin-1- yl)methyl)phenyl)but-2- enamide::US11993603, Example 24

SMILES C\C=C\C(=O)Nc1ccc(Cn2ncc3cnc(Nc4cnn(CCO)c4)nc23)cc1

InChI Key InChIKey=HVPQCGSFFCKBQH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677056   

TargetTyrosine-protein kinase JAK3(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677056(US11993603, Example 24 | N-(4-((6-((1-(2-hydroxyet...)
Affinity DataIC50: 0.200nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677056(US11993603, Example 24 | N-(4-((6-((1-(2-hydroxyet...)
Affinity DataIC50: 948nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677056(US11993603, Example 24 | N-(4-((6-((1-(2-hydroxyet...)
Affinity DataIC50: 1.12E+3nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent