BDBM677960 2-(1H-pyrazol-4- yl)-N-(1-pyridin- 4-yl-1H-pyrazol- 4-yl)-1,3- thiazole-4- carboxamide::US20240174679, Example 1-8

SMILES O=C(Nc1cnn(-c2ccncc2)c1)c1csc(-c2cn[nH]c2)n1

InChI Key InChIKey=GJOCUWJKWRWXTL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 677960   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 677960BDBM677960(US20240174679, Example 1-8 | 2-(1H-pyrazol-4- yl)-...)
Affinity DataIC50: 8.51nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent