BDBM678056 N-{1-[(2,2- difluorocyclopropyl) methyl]-3- (difluoromethyl)- 1H-pyrazol-4- yl}-2-(1H- pyrazol-4-yl)- 1,3-thiazole-4- carboxamide::US20240174679, Example 7-29

SMILES O=C(Nc1cn(CC2CC2(F)F)nc1C(F)F)c1csc(-c2cn[nH]c2)n1

InChI Key InChIKey=FIIUUKTXAQMXKM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678056   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 678056BDBM678056(US20240174679, Example 7-29 | N-{1-[(2,2- difluoro...)
Affinity DataIC50: 16.6nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent