BDBM678159 US20240174690, Example I-41

SMILES C[C@H](Oc1cc(nc(n1)-c1onc2c1CCC[C@@]21CCCc2sc(N)c(C#N)c12)N1CCN(C)C2(CC2)C1)[C@@H]1CCCN1C

InChI Key InChIKey=XCVQZXMDZXSNPZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 678159   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM678159(US20240174690, Example I-41)
Affinity DataIC50: 1nMAssay Description:These assays measure the inhibitory effect of compounds on KRAS mutant protein-protein interactions using the Alpha Screen technology by Perkin Elmer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetGTPase KRas/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM678159(US20240174690, Example I-41)
Affinity DataIC50: 5nMAssay Description:These assays measure the inhibitory effect of compounds on KRAS mutant protein-protein interactions using the Alpha Screen technology by Perkin Elmer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM678159(US20240174690, Example I-41)
Affinity DataIC50: 6nMAssay Description:These assays measure the inhibitory effect of compounds on KRAS mutant protein-protein interactions using the Alpha Screen technology by Perkin Elmer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent