BDBM681167 N-(4-((S*)-2-(3-Chloro-2-fluorophenyl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide (Isomer 1)::US20240199558, Example 3

SMILES CC(C)C[C@H](CO)Nc1nc(C[C@H](C)c2cccc(Cl)c2F)nc(NS(C)(=O)=O)n1

InChI Key InChIKey=SWGWMPRGEUXMTB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 681167   

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 681167BDBM681167(N-(4-((S*)-2-(3-Chloro-2-fluorophenyl)propyl)-6-((...)
Affinity DataIC50: 124nMAssay Description:CHO-hCX3CR1 membranes (5 μg per well) together with different concentrations of antagonistic compound were incubated in 50 mM HEPES (pH 7.4), 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 681167BDBM681167(N-(4-((S*)-2-(3-Chloro-2-fluorophenyl)propyl)-6-((...)
Affinity DataIC50: 448nMAssay Description:cell-based assay using HEK293-gfpPLD2 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details US Patent