BDBM681173 N-(4-((R*)-2-(5-Chloro-6-methoxypyridin-3-yl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide (Isomer 1)::US20240199558, Example 9

SMILES COc1ncc(cc1Cl)[C@H](C)Cc1nc(N[C@@H](CO)CC(C)C)nc(NS(C)(=O)=O)n1

InChI Key InChIKey=JNLZVRYRGPUBME-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 681173   

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 681173BDBM681173(N-(4-((R*)-2-(5-Chloro-6-methoxypyridin-3-yl)propy...)
Affinity DataIC50: 205nMAssay Description:CHO-hCX3CR1 membranes (5 μg per well) together with different concentrations of antagonistic compound were incubated in 50 mM HEPES (pH 7.4), 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 681173BDBM681173(N-(4-((R*)-2-(5-Chloro-6-methoxypyridin-3-yl)propy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details US Patent