BDBM681182 N-(4-(((R)-1-Hydroxy-4-methylpentan-2-yl)amino)-6-((S*)-2-(2-methoxypyridin-3-yl)propyl)-1,3,5-triazin-2-yl)methanesulfonamide (Isomer 2)::US20240199558, Example 18

SMILES COc1ncccc1[C@@H](C)Cc1nc(N[C@@H](CO)CC(C)C)nc(NS(C)(=O)=O)n1

InChI Key InChIKey=XHLIELHFQHBUQD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 681182   

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 681182BDBM681182(N-(4-(((R)-1-Hydroxy-4-methylpentan-2-yl)amino)-6-...)
Affinity DataIC50: 758nMAssay Description:CHO-hCX3CR1 membranes (5 μg per well) together with different concentrations of antagonistic compound were incubated in 50 mM HEPES (pH 7.4), 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 681182BDBM681182(N-(4-(((R)-1-Hydroxy-4-methylpentan-2-yl)amino)-6-...)
Affinity DataIC50: 1.67E+4nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details US Patent